Tramadol 377 – Top 12 Things That You Need to Know

Tramadol 377 – Top 12 Things That You Need to Know

Tramadol is the most prescribed medication for pain is the USA. Here are Top 12 things about tramadol that you need to know in 2020

  1. Prescription Medication

    Tramadol Prescription Medication
    Painkiller
    Tramadol
    is an approved prescription-only medication to treat moderate to severe pain in adults.

  2. Tramadol is for severe pain

    Tramadols are recommended only for pain severe in nature which may require an opioid analgesic and where no other pain killer is tolerated.


  3. Tramadol mechanism

    Tramadols inhibit the reuptake of two neurotransmitters, norepinephrine and serotonin, which presumably adds to its pain relief capability, however the exact mechanism is still not known.

    Tramadol 377 pill / Capsules contains the active substance, the ingredient that makes the tablet work.

    • Pregelatinized starch
    • Microcrystalline cellulose (E460)
    • Magnesium stearate

  4. FDA Approved

    Tramadol 377 was originally approved in 1995 by the FDA as a non-controlled substance. However, due to its addictive nature and large scale reported abuse, and criminal diversions, later on, the drug is converted and classified as a controlled substance in
    schedule IV on the Controlled Substance Act (CSA). Ultram, however, is still safer than the substances included in schedule III and II of CSA.

  5. Common Side-effects of Tramadol

    • headache
    • itching
    • nausea
    • vomiting
    • constipation
    • diarrhea
    • dizziness
    • sleepiness
    • nervousness, anxiety, agitation

  6. Serious but rare side-effects of Tramadol

    • Ultra-rapid metabolism
    • break down of the drug in the body for elimination
    • Neonatal opioid withdrawal syndrome
    • Sedative-CNS depressant drugs
    • serotonin syndrome
    • seizures
    • adrenal insufficiency
    • severe hypotension
    • low blood pressure
    • androgen deficiency
    • severe hypersensitivity
    • allergic reactions


  7. Caution for Children below 12 years

    Tramadol’s branded versions like Ultram; ConZip should not be administered by children below 12 years

    Life-threatening respiratory depression, fatal repercussions, may result in death.

  8. Tramadols are not recommended for children up to 18 years

    tramadol adult dosageAvoid the use of Tramadol 377 as much as possible for children between 12 to 18 years without a doctor’s supervision.


  9. Risk factors if  administered by children below 18 years.

    • Respiratory depression after surgery
    • Obstructive sleep apnea
    • Obesity
    • Severe lung disease
    • Neuromuscular disease
    • Respiratory depression (slowed or stopped breathing)

  10. Caution for elderly

    Elderly who have the following should not administer this drug
    • Lowered liver function
    • Lowered kidney function
    • Reduced metabolism
    • Excretion

  11. How to take Tramadol – Administration

    Tramadols tablets or Tramadol 377 capsules need to be swallowed as a whole and not chewed, crushed inside the mouth or broken inside the mouth. This will induce an increased metabolism and faster bloodstream concentration of the drug may cause overdose or respiratory depression.

    A rapid or an ultra metabolizer should not take this drug.

  12. Generic Tramadols Doses Online in USA

    Tramadol 377 pill Dosage in USAGeneric options:

    50mg regular release tablets

    100mg regular release tablets

    Extended-release capsules -Tramadols 100mg, 150mg, 200mg, and 300mg

    Tramadols extended-release tablets 100mg, 200mg, and 300 mg

    Last but not least, you need dose adjustments while treating the elderly, and in those with kidney or liver problems.

    What capsules contain is the active substance, the ingredient that makes the tablet work.

    The other ingredients are

    • Pregelatinized starch
    • Microcrystalline cellulose (E460)
    • Magnesium stearate

    Related Blog – How effective is Tramadol against back pain

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